Dr. Niko Beerenwinkel, Professor at the Department of Biosystems Science and Engineering, ETH Zürich, Switzerland, will present the lecture "Learning tumor phylogenies from single-cell data."
Meeting Dr. Beerenwinkel If you want to meet Dr. Niko Beerenwinkel on Nov. 21st afternoon, please book a time slot at https://doodle.com/poll/6hut3wnhekkvvfqv and send an email to anthony.mathelier@ncmm.uio.no.
Abstract Cancer progression is an evolutionary process characterized by the accumulation of genetic alterations and responsible for tumor growth, clinical progression, and drug resistance development. We discuss how to reconstruct the evolutionary history of a tumor from single-cell sequencing data. The tumor phylogeny problem is challenging because of sequencing errors and the high rate of allelic drop-out in single-cell DNA sequencing experiments. We present probabilistic models and efficient inference algorithms for mutation calling and learning tumor phylogenies from mutation and copy number data.
